ALERT

Welcome to Pitt’s iLab system, established on 10 August 2024.  Pitt’s iLab is integrated into our single sign on system and our billing backends, tying faculty and staff grants to reserved time and services.

As of August 2025, we have 16 shared research facilities online!  

Looking ahead, by the end of fall 2025 we will have 30+ shared research facilities in our system, and we will offer training classes for faculty, staff and students at Pitt. 

This summer we will update the department of all Pitt employees using a standardized naming convention - please do not modify that field.  We are using it to build templates enabling automated reporting.

Please review our new Shared Facilities webpage and the iLab training material available in the “Using Core Facilities” section.

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Peptide and Peptoid Synthesis Core

Overview of Services


Peptides
Peptides can be produced at standard scales of 25umole (10-20mg), 50umole (20-50mg), 0.1mmole (50-100mg), 0.25mmole (100-200mg), and 0.50mmole (200mg plus), with actual yields dependent on peptide length and content. Automated peptide synthesis begins with chain elongation of the primary peptide sequence on polystyrene based solid supports (Solid Phase Peptide Synthesis). In addition, orthogonal de-protection strategies can be utilized either on-resin or in solution to incorporate a variety of peptide modifications in support of specific user requirements.

Peptoids
Peptoids are a class peptidomimetic compounds classified as poly N-substituted glycines which possess desirable chemical properties such as proteolytic resistance and the propensity to self-assemble into unique nanostructures. Automated peptoid synthesis can be performed on polystyrene based solid supports at either 0.1mmole or 0.25mmole scales with chain elongation occurring via substitution reactions utilizing user defined primary amine containing monomer units. Due to the large number of amine containing compounds commercially available virtually limitless combinations of peptoid sequences can be prepared and tailored to any research application.

Leadership

Thomas Smithgall, PhD, Director
412-648-8106

Location and hours of operation

Hours      Location

M-F 9:30-5:30

     300 Technology Drive
     Pittsburgh PA 15219

Links and Resources

  1. https://www.peptide.pitt.edu/

Contacts

Name Role Phone Email Location
Thomas Smithgall, PhD
Director
 
412-648-8106
 
tsmithga@pitt.edu
 
300 Technology Drive Pittsburgh PA 15219
 

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